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April 4, 2013Circulation ResearchOpen Access

Loss of p47 phox Subunit Enhances Susceptibility to Biomechanical Stress and Heart Failure Because of Dysregulation of Cortactin and Actin Filaments

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Population

Eight-week-old male p47 null (p47 knockout [KO]), Nox2 null, and wild-type mice, as well as murine and human…

Comparison

Transverse aortic constriction-induced pressure… vs Wild-type mice subjected to transverse aortic…

Design

Preclinical

Follow-up

5 and 9 weeks

Authors

VPVaibhav B. PatelUniversity of CalgaryZWZuocheng WangXiamen UniversityFDFan DongUniversity of Vermont

Discussion

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Overview

p47(phox) protects against pressure-overload dysfunction in mice; leaves open its relevance as a therapeutic target in human heart failure.

Structured PICO

P
Population
Eight-week-old male p47(phox) null (p47(phox) knockout [KO]), Nox2 null (Nox2KO), and wild-type mice, as well as murine and human heart samples.
I
Intervention
Transverse aortic constriction (TAC)-induced pressure overload in p47(phox)KO and Nox2KO mice
C
Comparator
Wild-type mice subjected to transverse aortic constriction
O
Outcome
Systolic dysfunction and cytoskeletal remodeling in response to pressure overloadsurrogate

The p47(phox) subunit plays a novel, Nox2-independent role in adaptive cytoskeletal remodeling, and its loss paradoxically enhances susceptibility to biomechanical stress and heart failure.

Cite This Study

Patel et al. (2013) studied this question.

synapsesocial.com/papers/6a7d67fde9ddcd9870aa1ee4https://doi.org/10.1161/circresaha.111.300299
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1p47phox-Dependent Oxidant Signalling through ASK1, MKK3/6 and MAPKs in Angiotensin II-Induced Cardiac Hypertrophy and Apoptosis2021 · 24 citations
  2. 2Loss of NOX2 (gp91<i>phox</i>) prevents oxidative stress and progression to advanced heart failure2014 · 57 citations
  3. 3Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47phox NADPH oxidase subunit2011 · 83 citations
  4. 4NAD(P)H oxidase subunit p47phox is elevated, and p47phox knockout prevents diaphragm contractile dysfunction in heart failure2015 · 40 citations
  5. 5Critical Role of the NAD(P)H Oxidase Subunit p47 <sup> <i>phox</i> </sup> for Left Ventricular Remodeling/Dysfunction and Survival After Myocardial Infarction2007 · 206 citations