Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 24, 2015AJP Lung Cellular and Molecular PhysiologyOpen Access

NAD(P)H oxidase subunit p47phox is elevated, and p47phox knockout prevents diaphragm contractile dysfunction in heart failure

View Full Paper
Ask AI
Bookmark
Share

Key result

p47phox knockout prevents up to ~50% loss of diaphragm function in mice with CHF.

  • P<0.05

Why the study?

Does p47phox knockout prevent diaphragm contractile dysfunction in mice with chronic heart failure?

Population

Wild-type and p47phox knockout mice with chronic heart failure (CHF)

Comparison

p47phox knockout vs Wild-type mice with CHF

Design

Preclinical

Authors

BABumsoo AhnABAdam W. BeharryGFGregory S. Frye

Discussion

Loading...

Member takes

Overview

p47phox targeting may preserve diaphragm function in CHF; leaves open clinical translation pending human trials.

Structured PICO

Does p47phox knockout prevent diaphragm contractile dysfunction in mice with chronic heart failure?

P
Population
Wild-type and p47(phox) knockout mice evaluated for diaphragm contractile dysfunction in chronic heart failure.
I
Intervention
p47phox knockout
C
Comparator
Wild-type mice with CHF
O
Outcome
Diaphragm contractile function (isometric force, shortening velocity, and peak power) and extracellular oxidant emissionsurrogate

Main Result

p-value: p=<0.05

p47phox knockout prevents diaphragm contractile dysfunction in a murine model of chronic heart failure, identifying p47phox-dependent NAD(P)H oxidase as a potential therapeutic target for CHF-related exercise intolerance.

Cite This Study

Ahn et al. (2015) studied Chronic heart failure. p47(phox) knockout vs. Wild-type mice was evaluated on Diaphragm isometric force, shortening velocity, and peak power (p=<0.05). p47(phox) knockout prevented the 20-50% decrease in diaphragm isometric force, shortening velocity, and peak power elicited by chronic heart failure in mice (P<0.05).

synapsesocial.com/papers/6aa6957839a5015a928e59a2https://doi.org/10.1152/ajplung.00176.2015
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Skeletal muscle Nox4 knockout prevents and Nox2 knockout blunts loss of maximal diaphragm force in mice with heart failure with reduced ejection fraction2022 · 8 citations
  2. 2Loss of p47 <sup>phox</sup> Subunit Enhances Susceptibility to Biomechanical Stress and Heart Failure Because of Dysregulation of Cortactin and Actin Filaments2013 · 51 citations
  3. 3Critical Role of the NAD(P)H Oxidase Subunit p47 <sup> <i>phox</i> </sup> for Left Ventricular Remodeling/Dysfunction and Survival After Myocardial Infarction2007 · 206 citations
  4. 4Nox4 Knockout Does Not Prevent Diaphragm Atrophy, Contractile Dysfunction, or Mitochondrial Maladaptation in the Early Phase Post-Myocardial Infarction in Mice2021 · 7 citations
  5. 5Loss of NOX2 (gp91<i>phox</i>) prevents oxidative stress and progression to advanced heart failure2014 · 57 citations