Why the study?
Patients with chronic kidney disease frequently have symptoms of orthostatic hypotension, but data regarding orthostatic hypotension in this population remain limited.
Does low eGFR increase the risk of orthostatic hypotension in a community-based cohort?
Does low eGFR increase the risk of orthostatic hypotension in a community-based cohort?
Reduced renal function and adherence to a low-sodium diet are associated with an increased risk of orthostatic hypotension, highlighting the need for careful dietary and blood pressure management in CKD patients.
INTRODUCTION: Patients with chronic kidney disease (CKD) often experience symptoms consistent with orthostatic hypotension (OH); however, not much is known about OH in this population. Therefore, study analyzed OH prevalence and risk according to renal function decline. METHODS: A community-based cohort study was conducted using data from the Korean Genome and Epidemiology Study (KoGES). OH prevalence was assessed at baseline and at a 2-year follow-up across three estimated glomerular filtration rate (eGFR) categories: high (≥90 mL/min/1.73 m2, G1), moderate (60-89 mL/min/1.73 m2, G2), and low (<60 mL/min/1.73 m2, G3). RESULTS: Among 9,597 participants, baseline OH, 2-year OH, and persistent OH were evaluated within each eGFR group: high (n = 6,743), moderate (n = 2,758), and low (n = 96). The low eGFR group demonstrated the highest prevalence of baseline OH (n = 52, p = 0.024) and 2-year OH (n = 42, p = 0.002). This group also exhibited the largest decline in systolic blood pressure at both baseline and follow-up. In adjusted logistic regression, participants aged <50 years with low eGFR had 3.54-fold higher odds of OH (p = 0.035). Additionally, adherence to a low-sodium diet was associated with increased 2-year OH prevalence across groups (p = 0.001). CONCLUSION: The low eGFR group showed a higher baseline and follow-up OH prevalence. A low-sodium diet was also associated with elevated OH risk, underscoring the need for careful dietary management in patients with CKD.
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Park et al. (2025) studied this question.
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