What question did this study set out to answer?

To evaluate the diagnostic criteria, overall prevalence, and mortality risk associated with sarcopenia in end-stage renal disease patients receiving dialysis.

January 5, 2022Journal of Cachexia Sarcopenia and MuscleOpen Access

Diagnosis, prevalence, and mortality of sarcopenia in dialysis patients: a systematic review and meta‐analysis

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Implication

Meta-analysis reveals high sarcopenia prevalence and elevated mortality in dialysis patients, highlighting the need for standardized diagnostic criteria.

Key Points

To evaluate the diagnostic criteria, overall prevalence, and mortality risk associated with sarcopenia in end-stage renal disease patients receiving dialysis.
Searched Embase, MEDLINE, PubMed, and Cochrane Library from inception through May 8, 2021, for studies measuring muscle mass using instruments like DEXA, BIA, MRI, or body composition monitors.
Included 30 studies comprising 6,162 participants (mean age 47.5 to 77.5 years) with low to moderate risk of bias.
Calculated pooled prevalence and mortality hazard ratios (HR) using random-effects modeling, heterogeneity testing (I²), and meta-regression.
The overall pooled prevalence of sarcopenia was 28.5% (95% CI 22.9–34.1%), ranging from 25.9% under combined criteria to 34.6% using low muscle mass alone (P=0.247 between subgroups).
Sarcopenia defined by combined criteria was significantly associated with elevated mortality risk (HR 1.82, 95% CI 1.38–2.39, I²=26.3%).
Increased mortality risk was independently observed for low muscle mass alone (HR 1.61, 95% CI 1.31–1.99, I²=26.0%) and low muscle strength alone (HR 2.04, 95% CI 1.19–3.50, I²=80.4%).

Cite This Study

A 2022 study studied this question.

synapsesocial.com/papers/6a7d6989d3686d25b46e5bbd https://doi.org/10.1002/jcsm.12890

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Implication

Meta-analysis reveals high sarcopenia prevalence and elevated mortality in dialysis patients, highlighting the need for standardized diagnostic criteria.

Diagnosis, prevalence, and mortality of sarcopenia in dialysis patients: a systematic review and meta‐analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Diagnosis, prevalence, and mortality of sarcopenia in dialysis patients: a systematic review and meta‐analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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