Summary IgND, represented by a myeloma protein ND and γE-globulin, detected in and isolated from atopic patients' sera with reaginic activity, belong to the same immunoglobulin class, which is distinct from IgG, IgA, IgM and IgD. The antigenic determinants characteristic of the fifth immunoglobulin class, which should be designated IgE, are localized in the Fc portion of the molecule. The association of reaginic activity with IgE was confirmed by the fact that anti-γE globulin as well as an antiserum specific for the Fc portion of myeloma-IgND precipitated the reaginic factor in atopic patients' sera.
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Bennich et al. (1969) studied this question.