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The profound effects of chemotherapy on the combined dynamics of the hematological stem cells and their differentiated neutrophils is examined. G-CSF is often used to deal with this neutropenia and the response is highly variable. To shape the neutrophil response to chemotherapy and G-CSF, periodic parametric resonance is discussed. Periodic oscillation in neutrophil levels and the subharmonic 1:2 resonance phenomena are observed with the assumption of periodic chemotherapy is given. The work is aim to stimulate further investigations and the practical applications.
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Ma et al. (2016) studied this question.
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