Why the study?
Does sodium repletion suppress renin and aldosterone secretion independently of blood volume expansion in normal volunteers?
Population
6 normal volunteers maintained on a constant dietary intake
Comparison
Sequential phases: 1) dietary and… vs Baseline/control values
Design
Other
Authors
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Sodium repletion may suppress RAAS independently of volume status; leaves open tubular sodium sensing as a therapeutic target in hypertension.
Does sodium repletion suppress renin and aldosterone secretion independently of blood volume expansion in normal volunteers?
Sodium balance regulates renin and aldosterone secretion independently of total blood volume, suggesting a major role for intrarenal tubular sodium transport in RAAS regulation.
Bull et al. (1970) studied this question.
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