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October 23, 2018JCI InsightOpen Access

Early accumulation of oxidized CL (CLox) products was followed by hydrolytic reactions yielding monolyso-CLs (mCLs) and free fatty acids, acting as mutually synergistically enhancing components of mitochondrial injury.

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Population

Animal models of controlled cortical impact (CCI) and Barth syndrome (Tafazzin [Taz] deficiency)

Design

Preclinical

Authors

HCHonglu ChaoTATamil S. AnthonymuthuEKElizabeth Kenny

Discussion

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Overview

Hypothesis-generating for dual cardiolipin-targeted therapy in TBI; leaves open clinical translation and efficacy in humans.

Structured PICO

P
Population
Animal models of controlled cortical impact (CCI) and Barth syndrome (Tafazzin [Taz] deficiency)
I
Intervention
Genetic manipulation of major CL-, CLox-, and mCL-metabolizing enzymes (calcium-independent phospholipase A2γ and Taz)
O
Outcome
Cardiolipin (CL) modifications (oxidation and hydrolysis) during controlled cortical impactsurrogate

Cardiolipin oxidation and hydrolysis act synergistically in mitochondrial injury during traumatic brain injury, highlighting a potential target for combined therapeutic approaches.

Cite This Study

Chao et al. (2018) studied this question.

synapsesocial.com/papers/6a7d72b8ade38b7dc346e563https://doi.org/10.1172/jci.insight.97677
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cross-species evidence for cardiolipin remodeling in neonatal hypoxic–ischemic encephalopathy2026
  2. 2Role of cardiolipin alterations in mitochondrial dysfunction and disease2006 · 651 citations
  3. 3Cardiolipin clustering promotes mitochondrial membrane dynamics2024 · 5 citations
  4. 4P002: Exploring the role of cardiolipin metabolism in the brain through the lens of Barth syndrome and cardiolipin synthase deficiency*2026
  5. 5Cardiolipin Remodeling in Cardiovascular Diseases: Implication for Mitochondrial Dysfunction2025 · 8 citations