What question did this study set out to answer?

The research aims to assess if a macroscopically normal appendix should be removed during surgery for suspected appendicitis based on histological findings.

August 13, 2026Journal of Global Health Economics and PolicyOpen Access

Management of a macroscopically normal appendix during surgery for suspected appendicitis: Evidence for clinical practice, healthcare resource use and surgical policy

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The research aims to assess if a macroscopically normal appendix should be removed during surgery for suspected appendicitis based on histological findings.
Conducted a systematic review and meta-analysis according to PRISMA 2020 guidelines.
Reviewed experimental and observational studies published until March 2023.
Performed a random-effects meta-analysis to estimate incidences of appendicitis and significant pathology.
Pooled incidence of histologically confirmed acute appendicitis was 25% (95% CI 0.15–0.33).
Pooled incidence of overall clinically significant pathology was 28% (95% CI 0.20–0.37).
Other pathologies identified included neuroendocrine tumours and appendiceal neoplasms, highlighting significant heterogeneity.

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Implication

Systematic review analyzes appendectomies for normal appendix in suspected appendicitis, suggesting individualized decisions.

Cite This Study

A 2026 study studied this question.

synapsesocial.com/papers/6a7d75e62b0e0cff3f63ed26 https://doi.org/10.7189/001c.166234

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Management of a macroscopically normal appendix during surgery for suspected appendicitis: Evidence for clinical practice, healthcare resource use and surgical policy

Key Points

Discussion

Implication

Cite This Study

Management of a macroscopically normal appendix during surgery for suspected appendicitis: Evidence for clinical practice, healthcare resource use and surgical policy

Key Points

Discussion

Implication

Cite This Study

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