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August 13, 2026Korean Journal of OphthalmologyOpen Access

Comparison of Tear Fluid Vascular Endothelial Growth Factor and Corneal Neovascularization between Bacterial and Fungal Corneal Ulcers

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Overview

Randomized trial compares VEGF levels and neovascularization in bacterial and fungal corneal ulcers, suggesting differing angiogenesis.

Key Points

  • To compare tear fluid VEGF levels and corneal neovascularization between bacterial and fungal corneal ulcers.
  • Measured corneal neovascularization via ImageJ software at first visit and four weeks later.
  • Assessed VEGF-A concentrations using enzyme-linked immunosorbent assay in tear fluid samples.
  • Bacterial ulcers showed greater neovascularization at four weeks (21.6% vs 11.0%, p=0.033) but similar at the start (10.3% vs 8.0%, p=0.262).
  • No significant VEGF-A difference between groups at either time point (first visit p=0.391, fourth week p=0.792).
  • No correlation between VEGF-A levels and neovascularization area at both visits.

Cite This Study

A 2026 study studied this question.

synapsesocial.com/papers/6a7d75e62b0e0cff3f63ee45https://doi.org/10.3341/kjo.2026.0067
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