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August 10, 2026Critical Care Medicine

A 1-Hour Resuscitation Bundle for Prehospital Management of Septic Shock

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Key Points

To assess the effectiveness of a 1-hour resuscitation bundle in reducing 28-day mortality in adults with septic shock managed prehospitally.
Cluster-randomized, open-label study conducted in France from May 2016 to November 2018.
Included 381 adults with suspected septic shock treated by a mobile ICU team.
Intervention involved early antibiotics, fluid resuscitation, and vasopressor therapy within 1 hour.
28-day mortality was 22% in the resuscitation bundle arm versus 27% in usual care (risk ratio 0.81; 95% CI [0.61-1.08]; p = 0.16).
No significant differences in secondary outcomes related to mortality or healthcare utilization between groups.

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Implication

Investigates 1-hour resuscitation bundle’s impact on mortality in adults with septic shock, suggesting no reduction in death rates.

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Cite This Study

A 2026 study studied this question.

synapsesocial.com/papers/6a7d76062b0e0cff3f63f0a0 https://doi.org/10.1097/ccm.0000000000007283

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