Polygenic profiles in youth with early-onset psychosis and offspring of schizophrenia or bipolar disorder patients
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Overview
Randomized trial assesses genetic profiles impacting cognition and psychosis in youth, indicating significant findings for healthcare.
Key Points
The study aims to clarify genetic factors associated with early-onset psychosis and familial risk for psychotic disorders.
Assessed polygenic scores in 414 youth, including cases of early-onset psychosis and healthy controls.
Calculated polygenic scores using the PRS-CS tool and examined differences with binary logistic models.
Conducted sensitivity analyses to account for potential confounders.
Youth with non-affective early-onset psychoses showed significantly higher polygenic scores for schizophrenia (P FDR < 0.05).
Higher polygenic scores for ADHD were identified in youth with non-affective early-onset psychoses (P FDR < 0.05).
Lower polygenic scores for cognition and educational attainment were found in youth with non-affective early-onset psychoses compared to other groups (all P FDR < 0.05).