Retrospective case series reports increased muscle mass and strength in men with obesity and testosterone deficiency during weight loss intervention, suggesting positive outcomes.
Key Points
To determine if a program combining testosterone therapy and exercise preserves skeletal muscle mass during incretin-mediated weight loss.
Retrospective case series of 93 men with obesity and testosterone deficiency treated with tirzepatide and testosterone.
Participants received weekly treatments, exercise coaching, and dietary guidance over 12 months.
Body composition and grip strength were assessed at baseline and follow-up intervals.
Body weight decreased by 20.9-22.6 kg (18-20%) and fat mass by 16.6-17.1 kg (38-40%).
Skeletal muscle mass increased by 1.6-3.7 kg (4-12%) while lean body mass decreased by 4.0-6.1 kg.
Grip strength improved by 5.7-7.1 kg (18-21%) and HbA1c levels in diabetes patients dropped from 10.1% to 5.8%.