PPARs modulate cardiac metabolism and mitochondrial function in diabetes

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Population

Diabetic cardiomyopathy

Design

Review

Authors

Discussion

Requires clinical caution with synthetic PPAR agonists in metabolic disease; leaves open mitochondrial targeting in diabetic cardiomyopathy.

Population

Diabetic cardiomyopathy

Intervention

PPAR agonists

Outcome

Mitochondrial function and cardiac metabolism

This review highlights the complex and controversial role of PPAR agonists in modulating mitochondrial function in diabetic cardiomyopathy.

Lee et al. (2017) studied this question.

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Requires clinical caution with synthetic PPAR agonists in metabolic disease; leaves open mitochondrial targeting in diabetic cardiomyopathy.