July 27, 2012Toxicological SciencesOpen Access

Characterization of Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes: Bioenergetics and Utilization in Safety Screening

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Population

Human-induced pluripotent stem cell (iPSC) derived cardiomyocytes

Design

Preclinical

Authors

PRPayal RanaNational Institute of Immunology BABlake D. AnsonFujifilm (Japan)SESandra J. EngleBiogen (United States)

Discussion

Member takes

Implication

Supports galactose iPSC-CM screening for kinase inhibitor cardiotoxicity; leaves open clinical translation.

Structured PICO

Population

Human-induced pluripotent stem cell (iPSC) derived cardiomyocytes

Intervention

Kinase inhibitors with known clinical cardiac liabilities (sorafenib, sunitinib, dasatinib, imatinib, lapatinib, and nilotinib)

Outcome

Mitochondrial function and dose-dependent toxicity (oxygen consumption rates and ATP production)safety

Human iPSC-derived cardiomyocytes cultured in galactose provide a bioenergetically relevant model for preclinical safety screening of cardiotoxic drugs.

Cite This Study

Rana et al. (2012) studied this question.

synapsesocial.com/papers/6a7d764da88f8d6a78a01555 https://doi.org/10.1093/toxsci/kfs233

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Characterization of Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes: Bioenergetics and Utilization in Safety Screening

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes: Bioenergetics and Utilization in Safety Screening

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider