Randomized trial demonstrates the effectiveness of rhodium catalysis in forming dihydroisoquinolinones and benzodiazepinones.
Rh(III)‐catalyzed redox‐neutral cascade C─H functionalization and annulation of arylamides with sulfoxonium ylides has been accomplished to produce 3,4‐dihydroisoquinolinones, which can be skeletal edited to furnish diazepinone structual frameworks. Substrate scope, functional group diversity, scalability, and late‐stage functionalization of the annulated products are the important practical features.
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Muthuraja et al. (2026) studied this question.
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