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August 13, 2026Physiological GenomicsOpen Access

Epigenomic patterns in fish with divergent cortisol reactivity

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Authors

SCSélim Ben ChehidaΑΣΑθανάσιος ΣαμαράςMKMadoka V. Krick

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Overview

Randomized trial investigates epigenetic changes in fish with differing cortisol responses, suggesting potential biomarkers for stress.

Key Points

  • The study aims to explore the epigenetic profiles of fish with differing cortisol responses to stress.
  • Measured cortisol levels in 400 European seabass to select individuals with low and high reactivity.
  • Evaluated weight, lysozyme activity, and plasma glucose and lactate levels.
  • Investigated the methylome at 41,132 CpG positions in blood samples before and after stress challenges.
  • Identified 273 differentially methylated cytosines associated with 159 annotated genes.
  • Categorized differential methylation as 'constitutive' or 'induced', distinguishing among stress responses.
  • Noted seven differentially methylated genes changed from hypo- to hypermethylation, relevant to cortisol signaling.

Cite This Study

Chehida et al. (2026) studied this question.

synapsesocial.com/papers/6a7d769b2b0e0cff3f6401ddhttps://doi.org/10.1152/physiolgenomics.00298.2025
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