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August 13, 2026PLOS Global Public HealthOpen Access

Computer-aided detection pragmatic threshold calibration in TB active case finding: A mixed-methods study in Tondo, Manila

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Authors

VCValentina CarnimeoEPEmelie Love Yonally PhillipsDGDanica Katrina Galvan

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Overview

Mixed-methods study calibrating CAD thresholds improved TB detection efficiency in underserved populations.

Key Points

  • This study aimed to develop and evaluate a practical approach for calibrating CAD thresholds in TB active case finding.
  • Mixed-methods approach incorporating retrospective analysis of pre-CAD data and prospective monitoring.
  • Semi-structured interviews with healthcare workers and stakeholders to inform threshold adjustments.
  • Integration of CAD4TB software into TB screening activities targeting individuals aged 15 and above in Tondo.
  • Initial CAD threshold of 25 resulted in a 35% referral rate; adjusted to 28 after two weeks with a new referral rate of 37.5%.
  • Post-adjustment, screening yield was 4.9% after 8 months; yield dropped to 4.2% when threshold increased to 32.
  • Overall, 14,739 individuals screened resulted in a total of 633 confirmed TB cases with a 4.3% screening yield.

Cite This Study

Carnimeo et al. (2026) studied this question.

synapsesocial.com/papers/6a7d76bd2b0e0cff3f64042dhttps://doi.org/10.1371/journal.pgph.0006908
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