Correlations of Free Beta Human Chorionic Gonadotropin/Pregnancy-Associated Plasma Protein A Ratio, Pregnancy Characteristics and Placental Pathology in Fetal Growth Restriction.

August 10, 2026

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This research aims to identify correlations between the FBHCG/PAPP-A ratio and placental pathology in fetal growth restriction (FGR).
Analyzed 69 pregnancies complicated with FGR.
Measured serum FBHCG/PAPP-A ratio between 11+0 and 13+6 weeks of gestation.
Correlated different FGR indicators with the FBHCG/PAPP-A ratio.
Higher FBHCG/PAPP-A ratio linked to increased prevalence of preeclampsia (p < 0.001) and low birth weight (p < 0.001).
Significantly lower placental weight to birth weight ratio (<1:8) observed with higher FBHCG/PAPP-A.
Distal villous hypoplasia and avascular villi significantly associated with higher FBHCG/PAPP-A ratio.

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Evaluates placental pathology in pregnancies affected by fetal growth restriction, highlighting potential early markers for monitoring.

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Dankó et al. (2026) studied this question.

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