What is the clinical evidence from this study?

Study design: Case Report. Population: Giant left atrial myxoma causing functional mitral stenosis (n=1). Intervention: Surgical resection. Primary outcome: Symptom resolution and tumor resection.

What does this research mean for the field?

Surgical resection of a giant left atrial myxoma causing functional mitral stenosis via dynamic ball-valve obstruction leads to complete symptom resolution. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Describe the clinical presentation, dynamic hemodynamics, and surgical management of a giant left atrial myxoma mimicking severe valvular mitral stenosis.

August 13, 2026CureusOpen Access

When a Cardiac Tumor Mimics Valvular Disease: Giant Left Atrial Myxoma Causing Functional Mitral Stenosis

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Key result

Surgical resection of giant left atrial myxoma achieves complete symptom resolution without recurrence.

Why the study?

Cardiac myxomas often present with nonspecific manifestations leading to delayed diagnosis, and large left atrial myxomas can rarely mimic valvular heart disease by causing dynamic transmitral flow obstruction.

Population

46-year-old previously healthy woman with progressive exertional dyspnea and orthopnea

Design

Case report

Authors

MSMarco Antonio Rodriguez SanchezAutonomous University of Sinaloa ASAlejandro Cortés SáinzAutonomous University of Sinaloa DCDavid Alejandro González CarrilloAutonomous University of Sinaloa

Discussion

Member takes

Implication

Supports surgical resection for symptom resolution in giant left atrial myxoma; hypothesis-generating and leaves open need for larger confirmatory studies.

Key Points

Describe the clinical presentation, dynamic hemodynamics, and surgical management of a giant left atrial myxoma mimicking severe valvular mitral stenosis.
Evaluated a 46-year-old previously healthy woman presenting with progressive exertional dyspnea and orthopnea using transthoracic echocardiography and laboratory testing.
Performed surgical resection of the intracardiac mass with histopathological evaluation and serial postoperative echocardiographic follow-up.
Transthoracic echocardiography revealed a mass measuring 69 × 34 × 31 mm attached to the interatrial septum that prolapsed into the left ventricle during diastole.
The dynamic ball-valve obstruction generated a mean transmitral gradient of 9.81 mmHg, accompanied by an initial B-type natriuretic peptide level of 548 pg/mL.
Complete surgical excision resolved all symptoms, leaving the patient in NYHA functional class I without residual obstruction during postoperative follow-up.

Study Design

Type

Case Report (n=1)

Multicenter

Structured PICO

Population

A 46-year-old previously healthy woman presenting with progressive exertional dyspnea and orthopnea due to a giant left atrial myxoma causing functional mitral stenosis.

Intervention

Surgical resection of the left atrial mass

Outcome

Complete symptom resolution and complete resection of the intracardiac mass

Giant left atrial myxomas can mimic primary mitral stenosis through a dynamic ball-valve mechanism, and prompt echocardiographic diagnosis followed by surgical resection leads to complete symptom resolution.

Limitations

As a single-case report, its findings cannot be generalized to all patients with giant left atrial myxomas causing functional mitral stenosis.
The duration of follow-up remains relatively limited for assessing long-term outcomes.
Additional imaging modalities such as transesophageal echocardiography, cardiac computed tomography, or cardiac magnetic resonance imaging were not performed.
Single-case report, findings cannot be generalized to all patients with giant left atrial myxomas
Limited duration of follow-up for assessing long-term outcomes
Additional imaging modalities such as transesophageal echocardiography, cardiac CT, or cardiac MRI were not performed

Cite This Study

Sanchez et al. (2026) conducted a case report in Giant left atrial myxoma causing functional mitral stenosis (n=1). Surgical resection was evaluated on Symptom resolution and tumor resection. Surgical resection of a giant left atrial myxoma causing functional mitral stenosis resulted in complete symptom resolution and no evidence of tumor recurrence.

synapsesocial.com/papers/6a7d76bd2b0e0cff3f64055a https://doi.org/10.7759/cureus.114317

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Implication

Supports surgical resection for symptom resolution in giant left atrial myxoma; hypothesis-generating and leaves open need for larger confirmatory studies.

When a Cardiac Tumor Mimics Valvular Disease: Giant Left Atrial Myxoma Causing Functional Mitral Stenosis

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

When a Cardiac Tumor Mimics Valvular Disease: Giant Left Atrial Myxoma Causing Functional Mitral Stenosis

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

Also Consider

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