Immunoglobulin G4 sclerosing disease of the spine in a young patient: illustrative case

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Key Points

This case illustrates uncommon features of immunoglobulin G4-related disease (IgG4-RD) with spinal involvement in a young patient.
Illustrative case report of a 23-year-old female with IgG4-RD and atypical spinal manifestations
Interventions included glucocorticoids and rituximab; management included diagnostic evaluations and cultures
Followed patient progression to identify complications and required interventions
Patient presented with discitis and osteomyelitis due to IgG4-RD, complicated by a Staphylococcus aureus infection
Initial treatment with glucocorticoids led to improvement, followed by worsening symptoms despite continued rituximab
Highlights the need for reevaluating IgG4-RD patients on immunosuppressive therapy for potential infections

Illustrative case reveals rare spinal involvement of IgG4-RD in a young female, highlighting diagnostic challenges and implications.

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Eldeeb et al. (2026) studied this question.

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