August 1, 1995Journal of VirologyOpen Access

Construction and genetic analysis of dicistronic polioviruses containing open reading frames for epitopes of human immunodeficiency virus type 1 gp120

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Population

Dicistronic polioviruses (pPNENPO and pDI-E2A derivatives) and cultured cells

Design

Preclinical

Authors

HLH H LuChinese Preventive Medicine Association LALouis AlexanderUniversity of Fribourg EWEckard WimmerCalifornia Institute of Technology

Discussion

Member takes

Implication

Hypothesis-generating for poliovirus-based HIV epitope vectors; requires validation in higher-level studies before clinical consideration.

Structured PICO

Population

Dicistronic polioviruses (pPNENPO and pDI-E2A derivatives) and cultured cells

Intervention

Insertion of foreign genetic elements (truncated HIV-1 gp120 or chloramphenicol acetyltransferase) with or without N-terminal secretory pathway signal sequence

Outcome

Viral viability and RNA synthesissurrogate

Dicistronic polioviruses can stably express small foreign epitopes like the principal neutralization determinant of HIV-1, suggesting potential as vaccine vectors.

Cite This Study

Lu et al. (1995) studied this question.

synapsesocial.com/papers/6a7d7a172c71273e4183eecd https://doi.org/10.1128/jvi.69.8.4797-4806.1995

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Implication

Hypothesis-generating for poliovirus-based HIV epitope vectors; requires validation in higher-level studies before clinical consideration.

Construction and genetic analysis of dicistronic polioviruses containing open reading frames for epitopes of human immunodeficiency virus type 1 gp120

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Construction and genetic analysis of dicistronic polioviruses containing open reading frames for epitopes of human immunodeficiency virus type 1 gp120

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider