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August 1, 2026Journal of Cardiovascular Magnetic ResonanceOpen Access

FAST-CMR evaluates 5D FISS-FRF precision versus conventional 2D cine CMR for assessing LVEF.

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Why the study?

The generalizability and clinical utility of the 5D FISS-FRF approach for cardiac magnetic resonance in a multi-center, multi-vendor setting has not yet been established.

Does 5D FISS-FRF provide comparable LVEF measurements to conventional 2D cine CMR in patients with cardiac disease?

Population

300 patients with cardiac disease across 21 international sites

Comparison

Post-contrast 5D FISS-FRF acquisition vs conventional 2D cine bSSFP CMR

Design

Prospective, observational, intra-individually controlled, pragmatic multi-center study with blinded core laboratory analysis

Key result

The FAST-CMR study is a prospective, multi-center observational protocol designed to evaluate the precision of 5D FISS-FRF compared to conventional 2D cine CMR for assessing LVEF in 300 patients.

Authors

KEKaterina EyreKKKenan KayaTCThomas Coudert

Discussion

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Overview

May simplify CMR acquisition without ECG or breath-holds; leaves open clinical adoption pending validation studies.

Key Points

  • To assess the multi-center, multi-vendor precision and agreement of a free-breathing 5D fast interrupted steady-state free-running framework against conventional 2D cine cardiac magnetic resonance imaging.
  • Prospective, observational, intra-individually controlled pragmatic trial enrolling 300 patients with cardiac disease across 21 international sites from 6 continents using 1.5T scanners from Siemens Healthineers and Philips Healthcare.
  • Patients are stratified equally across three clinical cohorts: congenital heart disease, patients unable to breath-hold, and patients able to breath-hold.
  • Each subject undergoes conventional 2D cine balanced steady-state free precession imaging and a six-minute post-contrast 5D FISS-FRF acquisition, followed by centralized raw data reconstruction and blinded core laboratory analysis.
  • The primary endpoint evaluates the precision of the mean paired within-subject difference in left ventricular ejection fraction between 5D FISS-FRF and conventional 2D cine imaging using confidence intervals and Bland-Altman analysis.
  • Secondary endpoints assess regional wall-motion abnormalities, overall image quality, scan efficiency, patient comfort, left ventricular mass, atrial volumes, and automated artificial intelligence reconstruction feasibility.
  • As an international trial protocol, formal quantitative effect sizes and numerical agreement metrics across vendors and cohorts will be determined upon completion of patient recruitment.

Study Design

Type

Observational (n=300)

Blinding

Blinded analysis

Multicenter

Yes

Structured PICO

Does 5D FISS-FRF provide comparable LVEF measurements to conventional 2D cine CMR in patients with cardiac disease?

P
Population
300 patients with cardiac disease, stratified by congenital heart disease and breath-holding ability, enrolled across 21 international sites to undergo intra-individual comparison of CMR techniques.
E
Exposure
Post-contrast 5D fast interrupted steady-state free-running framework (FISS-FRF) acquisition of six minutes in length
C
Comparator
Conventional 2D cine balanced steady-state free precession (bSSFP) CMR in both short-axis and long-axis orientations
O
Outcome
Precision of the mean paired difference in left ventricular ejection fraction (LVEF) between 5D FISS-FRF and conventional 2D cine CMR, assessed on a within-subject basissurrogate

The FAST-CMR study will evaluate whether a novel 5D free-running MRI framework can provide comparable ventricular function measurements to conventional 2D cine imaging without requiring ECG gating or breath-holding.

Cite This Study

Eyre et al. (2026) conducted an observational in Cardiac disease (n=300). 5D FISS-FRF CMR vs. Conventional 2D cine bSSFP CMR was evaluated on Precision of the mean paired difference in left ventricular ejection fraction (LVEF) between 5D FISS-FRF and conventional 2D cine CMR. The FAST-CMR study is a prospective, multi-center observational protocol designed to evaluate the precision of 5D FISS-FRF compared to conventional 2D cine CMR for assessing LVEF in 300 patients.

synapsesocial.com/papers/6a7d7ba200c5c9efbcaa21d2https://doi.org/10.1016/j.jocmr.2026.102784
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Free-running Fast-Interrupted Steady-State 5D whole-heart MRI of congenital heart disease patients without the use of contrast agents2025
  2. 2Performance of Free-Running Cardiac and Respiratory Motion-Resolved Whole-Heart 5D MRI in Congenital Heart Disease Patients Using a Gadolinium Enhanced Fast-Interrupted Steady-State Sequence.2026
  3. 3Free-running 5D whole-heart MRI with ferumoxytol enhancement to evaluate cardiac function in congenital heart disease2024
  4. 4Value CMR: Towards a Comprehensive, Rapid, Cost-Effective Cardiovascular Magnetic Resonance Imaging2021 · 20 citations
  5. 5Standard breath-hold versus free-breathing real-time cine cardiac MRI—a prospective randomized comparison in patients with known or suspected cardiac disease2025 · 9 citations