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January 1, 2005Synapse

Calcium inflow-dependent protein kinase C activity is involved in the modulation of transmitter release in the neuromuscular junction of the adult rat

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Population

Neuromuscular junctions of the levator auris longus muscle from adult rats

Comparison

Protein kinase C activators and inhibitors, with… vs Control conditions without PKC modulators

Design

Preclinical

Follow-up

1 to 7 hours

Authors

MSManel M. SantaféUniversitat Rovira i VirgiliMLMaria Angel LanuzaInstitut d'Investigació Sanitària Pere VirgiliNGNeus GarcíaCorporació Sanitària Parc Taulí

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Implication

Does not support clinical translation; leaves open PKC as a modulator of neuromuscular transmission pending human studies.

Structured PICO

P
Population
Neuromuscular junctions of the levator auris longus muscle from adult rats
I
Intervention
Protein kinase C activators (phorbol 12-myristate 13-acetate [PMA, 10 nM]) and inhibitors (Calphostin-C, 10 microM; Chelerythrine, 1 microM; Staurosporine, 200 nM), with or without calcium influx modulation (omega-Aga-IVA, magnesium)
C
Comparator
Control conditions without PKC modulators
O
Outcome
Quantal content of evoked endplate potentials (EPPs) and miniature endplate potentials (MEPPs)surrogate

Protein kinase C modulates acetylcholine release at the adult rat neuromuscular junction in a manner dependent on calcium inflow through P/Q-type voltage-dependent calcium channels.

Cite This Study

Santafé et al. (2005) studied this question.

synapsesocial.com/papers/6a7d7cea2c1f7923a7966070https://doi.org/10.1002/syn.20159
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of acetylcholine release by muscarinic receptors at the mouse neuromuscular junction depends on the activity of acetylcholinesterase2002 · 84 citations
  2. 2Adenosine Receptor Expression and Modulation of Ca2+Channels in Rat Striatal Cholinergic Interneurons2000 · 56 citations
  3. 3Protein Kinase C and Its 80‐Kilodalton Substrate Protein in Neuroblastoma Cell Neurite Outgrowth1990 · 37 citations