Why the study?
Do cis-fatty acids modulate voltage-dependent Na+ and Ca2+ currents in mouse neuroblastoma cells?
Population
N1E-115 mouse neuroblastoma cells
Comparison
cis-fatty acids (oleate, linoleate, linolenate) vs trans-isomer, saturated fatty acid, membrane…
Design
Preclinical
Authors
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Cis-fatty acid effects on Na+ currents are hypothesis-generating in neuroblastoma models; leaves open relevance to cardiac electrophysiology or clinical translation.
Do cis-fatty acids modulate voltage-dependent Na+ and Ca2+ currents in mouse neuroblastoma cells?
cis-Fatty acids attenuate voltage-dependent Na+ currents in mouse neuroblastoma cells via a mechanism involving protein kinase C activation.
Linden et al. (1989) studied this question.
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