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Focussed screening of known redox cyclers, and structurally related compounds, was performed using a horseradish peroxidase–phenol red (hydrogen peroxide) assay. A cell viability assay was then used to further understand structure-based toxicity. Pyrimidotriazinediones were confirmed as structural alerts and new redox cycling motifs were identified.
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Rana et al. (2013) studied this question.
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