Why the study?
To evaluate the effectiveness and safety of cryoballoon ablation compared with radiofrequency ablation for symptomatic paroxysmal or drug-refractory persistent atrial fibrillation.
Does cryoballoon ablation reduce atrial arrhythmia recurrence compared to radiofrequency ablation in patients with symptomatic paroxysmal or persistent atrial fibrillation?
Does cryoballoon ablation reduce atrial arrhythmia recurrence compared to radiofrequency ablation in patients with symptomatic paroxysmal or persistent atrial fibrillation?
In a prospective cohort study, cryoballoon ablation demonstrated similar overall efficacy to radiofrequency ablation for atrial fibrillation, with fewer re-ablations and adverse events during follow-up, but higher radiation exposure.
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Similar recurrence rates with CBA and RFA do not support changing ablation strategy; leaves open possible benefit in paroxysmal AF.
Hoffmann et al. (2019) studied this question.
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