What question did this study set out to answer?

To determine the molecular mechanisms by which epidermal growth factor (EGF) promotes head and neck squamous cell carcinoma (HNSCC) metastasis, focusing on the role of ANGPTL4.

October 31, 2016OncogeneOpen Access

Epidermal growth factor-induced ANGPTL4 enhances anoikis resistance and tumour metastasis in head and neck squamous cell carcinoma

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Population

Head and neck squamous cell carcinoma (HNSCC) cell lines and in vivo metastasis models

Comparison

EGF stimulation and ANGPTL4 modulation vs Control conditions

Design

Preclinical

Authors

YLY-H LiaoNational Cheng Kung University KCK-H ChiangChi Mei Medical Center JSJ-M ShiehChi Mei Medical Center

Discussion

Member takes

Implication

May support ANGPTL4 inhibition to limit HNSCC metastasis; leaves open clinical translation from animal data.

Key Points

To determine the molecular mechanisms by which epidermal growth factor (EGF) promotes head and neck squamous cell carcinoma (HNSCC) metastasis, focusing on the role of ANGPTL4.
Evaluated the impact of EGF stimulation and ANGPTL4 depletion on HNSCC anoikis resistance, migration, and invasion in vitro.
Investigated downstream matrix metalloproteinase regulation and integrin β1/AP-1 promoter signaling pathways.
Assessed tumor cell extravasation, lung metastatic seeding, and primary tumor growth in vivo following ANGPTL4 knockdown.
EGF induced ANGPTL4 expression, which significantly promoted anoikis resistance, cell migration, and cell invasion in HNSCC models.
Autocrine ANGPTL4 activated integrin β1 signaling to upregulate MMP-1 expression via an AP-1 binding site, while MMP-1 inhibition impeded cell motility.
Depletion of ANGPTL4 blocked EGF-primed tumor cell extravasation and metastatic seeding to the lungs, with no observed effect on primary tumor growth.

Structured PICO

Population

Head and neck squamous cell carcinoma (HNSCC) cell lines and in vivo metastasis models

Intervention

EGF stimulation and ANGPTL4 modulation (depletion or recombinant ANGPTL4)

Comparator

Control conditions

Outcome

Cancer cell migration, invasion, anoikis resistance, and metastasis (extravasation and metastatic seeding in lungs)surrogate

EGF-induced ANGPTL4 enhances HNSCC metastasis via MMP-1 up-regulation, suggesting ANGPTL4 inhibition as a potential therapeutic strategy for EGFR-mediated metastasis.

Cite This Study

Liao et al. (2016) studied this question.

synapsesocial.com/papers/6a7d849bcbfe537a718c8d25 https://doi.org/10.1038/onc.2016.371

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Epidermal growth factor-induced ANGPTL4 enhances anoikis resistance and tumour metastasis in head and neck squamous cell carcinoma

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Epidermal growth factor-induced ANGPTL4 enhances anoikis resistance and tumour metastasis in head and neck squamous cell carcinoma

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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