Key result
ANGPTL4 overexpression significantly increased cell invasion and decreased cisplatin-induced apoptosis in melanoma cells, effects that were reversed by knocking down ALDOA.
Why the study?
Does ANGPTL4 overexpression or knockdown affect cell invasion and survival in human melanoma cells?
Population
WM-115 and WM-266-4 human melanoma cell lines
Comparison
Overexpression and knockdown of ANGPTL4 vs Control cells (empty vector or scramble shRNA)
Design
Preclinical
Authors
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May identify ANGPTL4-ALDOA as melanoma vulnerability; hypothesis-generating and should not yet alter practice.
Does ANGPTL4 overexpression or knockdown affect cell invasion and survival in human melanoma cells?
p-value: p=<0.05
ANGPTL4 promotes melanoma cell invasion and survival against apoptotic stress by upregulating ALDOA expression through a PKC-dependent mechanism.
Sun et al. (2014) studied Melanoma. ANGPTL4 overexpression and knockdown vs. Control cells (empty vector or scramble shRNA) was evaluated on Cell invasion and apoptosis against cisplatin (p=<0.05). ANGPTL4 overexpression significantly increased cell invasion and decreased cisplatin-induced apoptosis in melanoma cells, effects that were reversed by knocking down ALDOA.
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