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November 6, 2005Journal of Biological ChemistryOpen Access

The Fasting-induced Adipose Factor/Angiopoietin-like Protein 4 Is Physically Associated with Lipoproteins and Governs Plasma Lipid Levels and Adiposity

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Why the study?

Does FIAF overexpression regulate lipid metabolism and adiposity in mice?

Population

Transgenic mice that mildly overexpress FIAF in peripheral tissues, and human samples

Comparison

Mild overexpression of FIAF in peripheral… vs Control mice (implied)

Design

Preclinical

Authors

SMStéphane MandardInsermFZFokko ZandbergenMaastricht UniversityESEsther van StratenUniversity Medical Center Groningen

Discussion

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Overview

FIAF overexpression links reduced adiposity to dyslipidemia in mice; leaves open therapeutic relevance in humans.

Structured PICO

Does FIAF overexpression regulate lipid metabolism and adiposity in mice?

P
Population
Transgenic mice that mildly overexpress FIAF in peripheral tissues, and human samples
I
Intervention
Mild overexpression of FIAF (fasting-induced adipose factor/angiopoietin-like protein 4) in peripheral tissues, with or without high fat diet
C
Comparator
Control mice (implied)
O
Outcome
Adipose tissue weight, plasma lipid levels (triglycerides, free fatty acids, glycerol, total cholesterol, HDL-cholesterol), and triglyceride clearancesurrogate

FIAF (Angptl4) acts as a powerful signal from fat and other tissues to prevent fat storage and stimulate fat mobilization, suggesting its disturbances may be involved in dyslipidemia.

Cite This Study

Mandard et al. (2005) studied this question.

synapsesocial.com/papers/6a70552ee5469ee92be11306https://doi.org/10.1074/jbc.m506519200
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis2000 · 283 citations
  2. 2Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance1993 · 7,546 citations
  3. 3Transgenic Angiopoietin-Like (Angptl)4 Overexpression and Targeted Disruption of Angptl4 and Angptl3: Regulation of Triglyceride Metabolism2005 · 434 citations
  4. 4Oligomerization state-dependent hyperlipidemic effect of angiopoietin-like protein 42004 · 117 citations
  5. 5Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the heart2005 · 114 citations