Why the study?
Does the C-terminal fibrinogen-like domain of Angptl4 stimulate adipose tissue lipolysis and reduce diet-induced obesity in mice?
Population
Mouse primary adipocytes and mice fed a high-fat diet (diet-induced obesity model)
Comparison
Purified C-terminal fibrinogen-like domain of… vs Control mice/cells (implied)
Design
Preclinical
Authors
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Separating the FLD from the CCD-mediated LPL-inhibitory activity of full-length Angptl4 reveals lipolytic and thermogenic properties with therapeutic relevance to obesity and diabetes.
Does the C-terminal fibrinogen-like domain of Angptl4 stimulate adipose tissue lipolysis and reduce diet-induced obesity in mice?
Separating the FLD from the CCD-mediated LPL-inhibitory activity of full-length Angptl4 reveals lipolytic and thermogenic properties with therapeutic relevance to obesity and diabetes.
Kanamaluru et al. (2017) studied this question.
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