Key result
Adipose tissue-specific deletion of ANGPTL4 in mice improved glucose tolerance, enhanced lipid clearance, and significantly reduced atherosclerotic plaque size compared to wild-type mice.
Population
Mice fed a high-fat diet (HFD)
Design
Preclinical
Follow-up
short-term
Authors
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Supports adipose ANGPTL4 as a cardiometabolic target; leaves open human translation pending clinical studies.
Adipose tissue-specific deletion of ANGPTL4 improves glucose tolerance and reduces atherosclerosis in mice, highlighting its role in peripheral lipid deposition and cardiometabolic disease.
Aryal et al. (2018) studied Atherosclerosis and metabolic disorders. Adipose tissue-specific ANGPTL4 knockout vs. Wild-type mice was evaluated on Atherosclerotic plaque size and glucose tolerance. Adipose tissue-specific deletion of ANGPTL4 in mice improved glucose tolerance, enhanced lipid clearance, and significantly reduced atherosclerotic plaque size compared to wild-type mice.
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