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April 12, 2021Scientific ReportsOpen Access

Regulation of plasma triglyceride partitioning by adipose-derived ANGPTL4 in mice

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Why the study?

Elevated plasma triglycerides are linked to metabolic disease and ANGPTL4 inhibits lipoprotein lipase, but the role of adipocyte-specific ANGPTL4 deficiency during high-fat diet feeding was unknown.

Population

Adipocyte-specific ANGPTL4 deficient mice and littermate controls

Comparison

Adipocyte-specific ANGPTL4 deficiency vs littermate controls during high fat diet feeding

Design

Preclinical animal study

Follow-up

12 weeks or 6 months

Authors

KSKathryn M. SpitlerUniversity of IowaSSShwetha K. ShettyUniversity of IowaECEmily M. CushingUniversity of Iowa

Discussion

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Implication

Adipocyte ANGPTL4 deficiency alters TG partitioning in HFD-fed mice; leaves open human relevance and therapeutic targeting.

Structured PICO

P
Population
Adipocyte-specific ANGPTL4 deficient mice and littermate controls
I
Intervention
High fat diet (60% kCal from fat) for 12 weeks or 6 months
C
Comparator
Littermate controls on the same diet
O
Outcome
Plasma metabolic measurements, triglyceride clearance and uptake, LPL activity, and glucose homeostasissurrogate

While adipocyte-derived ANGPTL4 regulates plasma triglyceride levels under normal conditions, its regulatory role is diminished after chronic high-fat feeding in mice.

Cite This Study

Spitler et al. (2021) studied this question.

synapsesocial.com/papers/6a7687523a7d5cabaf295dd3https://doi.org/10.1038/s41598-021-87020-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis2018 · 141 citations
  2. 2Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting2017 · 90 citations
  3. 3Characterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice2019 · 50 citations
  4. 4Loss of angiopoietin-like 4 (ANGPTL4) in mice with diet-induced obesity uncouples visceral obesity from glucose intolerance partly via the gut microbiota2018 · 100 citations
  5. 5Linking nutritional regulation of Angptl4, Gpihbp1, and Lmf1 to lipoprotein lipase activity in rodent adipose tissue2012 · 82 citations