Angptl4 is a glucocorticoid-responsive mediator of fasting-induced intracellular lipolysis that stimulates cAMP signaling in adipocytes, which may be relevant to diseases of aberrant lipolysis like insulin resistance.
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Angptl4 mediates fasting lipolysis in mice; hypothesis-generating for human insulin resistance and metabolic disease.
Gray et al. (2012) studied this question.
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