Key result
Adenovirus-mediated overexpression of Angptl4 in high-fat-diet mice reduced body weight gain (26.13g vs 28.0g) and improved glucose tolerance, but aggravated hepatic steatosis and hyperlipidemia.
Why the study?
Does Angptl4 overexpression improve glucose tolerance and lipid metabolism in high-fat-diet-induced obese mice?
Population
24 male C57BL/6 healthy mice, 8-10 weeks old, fed a high-fat diet to induce obesity and insulin resistance.
Comparison
Adenoviral vector for overexpression of Angptl4… vs Model control and normal control.
Design
Preclinical, Mice were divided into three groups randomly
Follow-up
2 weeks post-injection
Authors
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Angptl4 overexpression yields mixed metabolic effects in obese mice; leaves open its viability as a therapeutic target pending human studies.
Does Angptl4 overexpression improve glucose tolerance and lipid metabolism in high-fat-diet-induced obese mice?
Absolute Event Rate: 26.13% vs 28%
p-value: p=<0.01
Angptl4 overexpression in high-fat-diet mice improves glucose tolerance and insulin resistance but at the cost of inducing hyperlipidemia and liver steatosis.
Wang et al. (2016) studied High-fat-diet induced obesity (n=24). Adenoviral-Angptl4 vs. Adenovirus-injected HFD mice (model control) was evaluated on Body weight (g) (p=<0.01). Adenovirus-mediated overexpression of Angptl4 in high-fat-diet mice reduced body weight gain (26.13g vs 28.0g) and improved glucose tolerance, but aggravated hepatic steatosis and hyperlipidemia.
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