Population
High Five insect cell microsomes expressing SERCA2a with and without phospholamban, and native skeletal and…
Comparison
Expression of SERCA2a with phospholamban (PLB) vs Expression of SERCA2a without PLB, and native…
Design
Preclinical
Authors
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Does not support isoform-specific SERCA targeting; leaves open PLB modulation as primary research focus in cardiac calcium handling.
The kinetic differences in calcium transport between skeletal and cardiac sarcoplasmic reticulum are driven by the presence of phospholamban rather than intrinsic differences between SERCA1 and SERCA2a isoforms.
Mahaney et al. (2005) studied this question.
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