Key result
Epicardial adipose tissue thickness and left atrial fibrosis are significantly associated with markers of myocardial fibrosis, including MMP-9, TIMP-1, and TGF-β1, in patients with nonvalvular AF.
Why the study?
Does epicardial fat thickness and left atrial fibrosis correlate with profibrinogenic mediators in patients with nonvalvular atrial fibrillation without ischemic heart disease?
Cross-Sectional (n=39)
No
Does epicardial fat thickness and left atrial fibrosis correlate with profibrinogenic mediators in patients with nonvalvular atrial fibrillation without ischemic heart disease?
Effect estimate: τ=0.71
Epicardial fat thickness and left atrial fibrosis assessed by MRI correlate significantly with profibrinogenic markers (MMP-9, TIMP-1, TGF-β1) in patients with nonvalvular AF, suggesting early signs of atrial cardiomyopathy.
Hypothesis-generating for epicardial fat in AF cardiomyopathy; prospective studies needed before clinical or therapeutic implications.
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Голухова et al. (2018) conducted a cross-sectional in Nonvalvular atrial fibrillation (n=39). Epicardial adipose tissue thickness and left atrial fibrosis was evaluated on Correlation between epicardial adipose tissue thickness and biomarkers of fibrosis (MMP-9, TIMP-1, TGF-β1) (τ=0.71). Epicardial adipose tissue thickness and left atrial fibrosis are significantly associated with markers of myocardial fibrosis, including MMP-9, TIMP-1, and TGF-β1, in patients with nonvalvular AF.
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