What question did this study set out to answer?

To evaluate whether HDL functional quality provides a more accurate assessment of atheroprotection against cardiovascular disease than circulating HDL cholesterol concentrations.

January 1, 2008Journal of Atherosclerosis and ThrombosisOpen Access

Antiatherogenic Functionality of High Density Lipoprotein: How Much versus How Gooden-subtitle=

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Authors

DSDmitri SviridovGubkin Russian State University of Oil and Gas NMNigora MukhamedovaBaker Heart and Diabetes Institute ARAlan T. RemaleyPreventive Cardiology

Discussion

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Implication

Narrative review demonstrates that HDL functionality protects against cardiovascular disease independently of particle quantity, highlighting the need for direct functional assessments.

Key Points

To evaluate whether HDL functional quality provides a more accurate assessment of atheroprotection against cardiovascular disease than circulating HDL cholesterol concentrations.
Reviewed clinical and experimental evidence on HDL functionality, including cholesterol efflux capacity, antioxidant, anti-inflammatory, and anti-thrombotic properties.
Examined molecular mechanisms affecting particle quality, such as advanced glycation, oxidation, and alterations in HDL lipid and protein cargo.
HDL biological functionality operates partly independently of circulating plasma levels and deteriorates significantly during coronary artery disease, diabetes, and inflammation.
Because a single universal biomarker for multifaceted HDL activity does not exist, direct functional assays are required to determine true atheroprotective capacity.

Cite This Study

Sviridov et al. (2008) studied this question.

synapsesocial.com/papers/6a7d8ada75afeb5dc5339560 https://doi.org/10.5551/jat.e571

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January 1, 2008Journal of Atherosclerosis and ThrombosisOpen Access

Antiatherogenic Functionality of High Density Lipoprotein: How Much versus How Gooden-subtitle=

View Full Paper

Ask AI

Bookmark

Authors

DSDmitri SviridovGubkin Russian State University of Oil and Gas NMNigora MukhamedovaBaker Heart and Diabetes Institute ARAlan T. RemaleyPreventive Cardiology

Discussion

Member takes

Implication

Narrative review demonstrates that HDL functionality protects against cardiovascular disease independently of particle quantity, highlighting the need for direct functional assessments.

Key Points

To evaluate whether HDL functional quality provides a more accurate assessment of atheroprotection against cardiovascular disease than circulating HDL cholesterol concentrations.
Reviewed clinical and experimental evidence on HDL functionality, including cholesterol efflux capacity, antioxidant, anti-inflammatory, and anti-thrombotic properties.
Examined molecular mechanisms affecting particle quality, such as advanced glycation, oxidation, and alterations in HDL lipid and protein cargo.
HDL biological functionality operates partly independently of circulating plasma levels and deteriorates significantly during coronary artery disease, diabetes, and inflammation.
Because a single universal biomarker for multifaceted HDL activity does not exist, direct functional assays are required to determine true atheroprotective capacity.

Cite This Study

Sviridov et al. (2008) studied this question.

synapsesocial.com/papers/6a7d8ada75afeb5dc5339560 https://doi.org/10.5551/jat.e571

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