Key result
Type 2 diabetes mellitus with hyperlipidemia was associated with reduced left ventricular global longitudinal strain compared to healthy controls (20.1 vs 23.2, p<0.05), as well as significant reductions in left and right atrial strain.
Why the study?
The study was conducted to investigate the value of two-dimensional speckle tracking echocardiography in evaluating cardiac functions in type 2 diabetes mellitus with hyperlipidemia.
Does two-dimensional speckle tracking echocardiography detect early cardiac dysfunction in patients with type 2 diabetes mellitus and hyperlipidemia?
Cross-Sectional (n=90)
No
Does two-dimensional speckle tracking echocardiography detect early cardiac dysfunction in patients with type 2 diabetes mellitus and hyperlipidemia?
Absolute Event Rate: 20.1% vs 23.2%
p-value: p=<0.05
2D-STE reveals that left and right atrial global longitudinal strain are significantly reduced in T2DM patients with hyperlipidemia compared to those without, serving as potential early markers of cardiac dysfunction.
2D-STE may detect early cardiac dysfunction in T2DM with hyperlipidemia; leaves open prognostic value and need for prospective validation.
Background To investigate the value of two-dimensional speckle tracking echocardiography (2D-STE) in evaluating cardiac functions in type 2 diabetes mellitus (T2DM) with hyperlipidemia. Methods Sixty T2DM patients with normal left ventricular ejection fraction (LVEF) and poorly-controlled blood glucose were selected. Among these, thirty had hyperlipidemia. Thirty age- and gender-matched healthy individuals were recruited as the normal control group. Longitudinal strain of left ventricular segments, left ventricular global longitudinal strain (LV GLS), left atrial global longitudinal strain (LA GLS), right ventricular global longitudinal strain (RV GLS) and right atrial global longitudinal strain (RA GLS) were measured by 2D-STE. Results (1) Compared with the normal control group, LV GLS in T2DM group and T2DM with hyperlipidemia group decreased ( P < 0.05), but there was no significant difference of LV GLS between T2DM group and T2DM with hyperlipidemia group ( P > 0.05). Compared with the normal control group and T2DM group, longitudinal strain of middle segment of LV in T2DM with hyperlipidemia group decreased ( P < 0.05). (2) There was a significant difference in LA GLS among the three groups. LA GLS of T2DM with hyperlipidemia group was lower compared with the normal control and T2DM group ( P < 0.05). (3) Compared with the normal control group, RV GLS in T2DM group and T2DM with hyperlipidemia group was lower ( P < 0.05), but there was no significant difference of RV GLS between T2DM group and T2DM with hyperlipidemia group ( P > 0.05). RA GLS in T2DM with hyperlipidemia group decreased ( P < 0.05) compared to the normal control group and T2DM group. Conclusion Speckle tracking echocardiography can effectively evaluate cardiac dysfunction in patients with T2DM. LA GLS and RA GLS can be used as potential markers of cardiac dysfunction in T2DM with hyperlipidemia, and provide the basis for early clinical diagnosis and treatment.
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Dong et al. (2021) conducted a cross-sectional in Type 2 Diabetes Mellitus with Hyperlipidemia (n=90). Type 2 diabetes mellitus with hyperlipidemia vs. Healthy controls and T2DM without hyperlipidemia was evaluated on Left ventricular global longitudinal strain (LV GLS) (p=<0.05). Type 2 diabetes mellitus with hyperlipidemia was associated with reduced left ventricular global longitudinal strain compared to healthy controls (20.1 vs 23.2, p<0.05), as well as significant reductions in left and right atrial strain.
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