Wide surgical excision is the treatment of choice for low-grade cutaneous angiosarcoma, while undifferentiated types remain challenging to treat.
Supports consideration of wide excision in younger patients with low-grade disease; leaves open effective therapies for undifferentiated angiosarcomas in the elderly.
A clinicopathologic and histochemical analysis of 28 patients with one or multiple lesions of cutaneous angiosarcoma showing various stages of differentiation is presented the face and the scalp were the usual locations the tumors occurred most often in patients under the age of 20 and over the age of 60. Low-grade (well-differentiated) angiosarcomas occurred mainly in children and youth adults, but occasionally occurred also in older people in 3 children, the angiosarcomas arose in typical port-wine stains. Undifferentiated angiosarcomas occurred mainly in elderly individuals and were locally invasive and mutilating in our study, 3 children had this type of angiosarcoma. Metastases occurred in 4 of our 28 patients, usually after extensive local infiltration of the skin and soft tissues the proliferation of cells seemed to occur in a multicentric fashion. Wide surgical excision was the treatment of choice in low-grade angiosarcoma; whereas, in the undifferentiated type, no modality of treatment was consistently successful.
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Girard et al. (1970) studied this question.
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