October 1, 2002The American Journal of Surgical Pathology
Angiosarcoma Arising in Hemangioma/Vascular Malformation
Population
4 patients in the 6th or 7th decade of life presenting with an enlarging deep-seated mass diagnosed as…
Design
Case_series
Follow-up
2 and 14 months (reported for two patients)
Authors
Discussion
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Member takes
Implication
Rare angiosarcoma arising in benign hemangiomas warrants histologic vigilance; leaves open pathogenesis and management in larger cohorts.
Structured PICO
P
Population
4 patients in the 6th or 7th decade of life (2 female, 2 male) presenting with an enlarging deep-seated mass diagnosed as angiosarcoma arising in a hemangioma/vascular malformation.
I
Intervention
Marginal excision (3 cases) or biopsy (1 case), followed by radiotherapy/chemotherapy in all cases.
O
Outcome
Clinical presentation, treatment outcomes, and histological/immunohistochemical characteristics of the tumors.
Angiosarcoma can rarely arise within a pre-existing benign hemangioma or vascular malformation, presenting with distinct biphasic histological components.
Cite This Study
Rossi et al. (2002) studied this question.