Effects of a Single Administration of Acarbose on Postprandial Glucose Excursion and Endothelial Dysfunction in Type 2 Diabetic Patients: A Randomized Crossover Study

Diet-treated type 2 diabetic patients (n=14) and age- and sex-matched controls (n=12)

Single administration of acarbose prior to a test meal (total 450 kcal; protein 15.3%; fat 33.3%; carbohydrate 51.4%)

Test meal without prior acarbose administration (crossover design)

Postprandial metabolic parameters (peak glucose, plasma glucose excursion, change in AUC glucose) and endothelial function (peak forearm blood flow response and total reactive hyperemic flow during reactive hyperemia on strain-gauge plethysmography) up to 240 min after test mealsurrogate