Key result
Primary cardiac lymphoma was diagnosed in a 50-year-old man presenting with syncope, highlighting the importance of considering this rare malignancy in patients with unexplained cardiac masses.
Why the study?
Primary cardiac lymphoma is extremely rare and therapeutic options remain poorly defined, with clinical presentation and outcomes varying substantially.
Case Report (n=1)
No
This case highlights the importance of considering primary cardiac lymphoma in the differential diagnosis of patients presenting with unexplained cardiac symptoms, heart failure, and cardiac masses.
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Alerts clinicians to biopsy cardiac masses with effusions for primary lymphoma; leaves open optimal therapy and survival predictors.
Primary cardiac lymphoma, an extremely rare type of B-cell non-Hodgkin lymphoma, has an incidence of approximately 0.02-2% among malignant cardiac tumors. It is frequently associated with manifestations such as cardiac rhythm disturbances, refractory pericardial effusion and cardiac masses. Definitive diagnosis is achieved by biopsy, being essential to rule out hematogenous dissemination with PET-CT. The literature indicates a predominance of right chamber involvement and survival that varies significantly according to left ventricular involvement and the presence of arrhythmias. Therapeutic options are not well defined, but chemotherapy such as R-CHOP has shown efficacy, although the prognosis is generally poor due to complications such as disease progression, arrhythmias and sepsis. This case underscores the importance of considering cardiac lymphoma in patients with unexplained cardiac symptoms, highlighting the need for a multidisciplinary and specific diagnostic and therapeutic approach.
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Serna–Trejos et al. (2024) conducted a case report in Primary cardiac lymphoma (n=1). R-CVP chemotherapy was evaluated. Primary cardiac lymphoma was diagnosed in a 50-year-old man presenting with syncope, highlighting the importance of considering this rare malignancy in patients with unexplained cardiac masses.
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