Key result
A 54-year-old woman with a right atrial mass diagnosed as diffuse large B-cell lymphoma achieved a complete metabolic response after surgical excision and six cycles of R-CHOP chemotherapy.
Why the study?
Cardiac involvement in lymphoma is rare, typically presents late, and multimodality imaging is critical to distinguish cardiac masses for optimal treatment.
Case Report (n=1)
No
Surgical excision followed by R-CHOP chemotherapy resulted in a complete metabolic response in a rare case of right atrial diffuse large B-cell lymphoma presenting with hemodynamic compromise.
May inform rare cardiac lymphoma management; leaves open need for prospective validation.
Cardiac involvement in lymphoma is rare and usually presents as a late manifestation of the disease. Although clinically asymptomatic and mostly found on autopsy, some patients may present with ventricular outflow obstruction, valve dysfunction, arrhythmias, pericardial effusion, cardiac tamponade, and tumor embolization. Multimodality imaging is important in distinguishing cardiac masses to provide optimal treatment. Here, we describe the case of a 54-year-old woman who presented with dyspnea on exertion and hemodynamic compromise. With the aid of multimodality imaging, the patient was found to have a right atrial cardiac mass. Given her worsening symptoms and hemodynamic instability, the patient underwent excision of the right atrial mass. Ultimately, histopathology revealed diffuse large B-cell lymphoma. The patient was evaluated further and completed systemic therapy without any adverse events and achieved complete metabolic response (Deauville score 1). The patient completed her first-year follow-up, and an annual positron emission tomography-computed tomography showed no evidence of disease.
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S et al. (2025) conducted a case report in Diffuse large B-cell lymphoma with cardiac involvement (n=1). Surgical excision and R-CHOP chemotherapy was evaluated on Metabolic response. A 54-year-old woman with a right atrial mass diagnosed as diffuse large B-cell lymphoma achieved a complete metabolic response after surgical excision and six cycles of R-CHOP chemotherapy.
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