What question did this study set out to answer?

To examine the role of blinding and potential assessment bias during functional outcome evaluations in endovascular thrombectomy trials for acute ischemic stroke.

September 10, 2015New England Journal of MedicineOpen Access

Stent-Retriever Thrombectomy for Stroke

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Authors

JSJeffrey L Saver MGMayank Goyal HDHans-Christoph Diener

Discussion

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Implication

Correspondence highlights functional outcome assessment and blinding in acute ischemic stroke trials, indicating the risk of evaluation bias.

Key Points

To examine the role of blinding and potential assessment bias during functional outcome evaluations in endovascular thrombectomy trials for acute ischemic stroke.
Critique of the SWIFT PRIME phase 3 randomized clinical trial assessing stent-retriever thrombectomy in acute ischemic stroke.
Evaluation of patient and proxy blinding procedures during the administration of the modified Rankin scale.
The SWIFT PRIME trial demonstrated a substantial functional recovery benefit following stent-retriever endovascular treatment.
The subjective components of the modified Rankin scale underscore the necessity of blinding patients and proxies to prevent evaluation bias.

Cite This Study

Saver et al. (2015) studied this question.

synapsesocial.com/papers/6a7d8f32603f5e16dd3397fb https://doi.org/10.1056/nejmc1508744

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Implication

Correspondence highlights functional outcome assessment and blinding in acute ischemic stroke trials, indicating the risk of evaluation bias.

Stent-Retriever Thrombectomy for Stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

Stent-Retriever Thrombectomy for Stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

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