Key result
Among patients with Duchenne muscular dystrophy, prolonged survivors had significantly higher ejection fractions than those who experienced early death (42.2% vs 29.2%, P=0.035).
Why the study?
What are the cardiopulmonary determinants of prolonged survival in patients with Duchenne muscular dystrophy?
Observational (n=25)
No
What are the cardiopulmonary determinants of prolonged survival in patients with Duchenne muscular dystrophy?
Absolute Event Rate: 42.2% vs 29.2%
p-value: p=0.035
In Duchenne muscular dystrophy patients receiving assisted ventilation, preserved cardiac function is the primary determinant of prolonged survival beyond 30 years of age.
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Preserved LVEF was associated with prolonged survival in ventilated DMD; hypothesis-generating for cardiac optimization trials.
Birnkrant et al. (2015) conducted an observational in Duchenne muscular dystrophy (n=25). Prolonged survival (≥30 years old) vs. Early death (<30 years old) was evaluated on Ejection fraction (p=0.035). Among patients with Duchenne muscular dystrophy, prolonged survivors had significantly higher ejection fractions than those who experienced early death (42.2% vs 29.2%, P=0.035).
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