What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Cardiology outpatients (n=773). Intervention: Advancing age (≥75 years) vs. Age ≤64 years. Primary outcome: High prothrombin-fragment 1+2 (F1+2) level (≥230 pmol/L) (OR 11.611, 95% CI 7.143-19.183, p=<0.001).

January 1, 2016Circulation JournalOpen Access

Effects of Aging on the Coagulation Fibrinolytic System in Outpatients of the Cardiovascular Department

Q: What are the key findings of this study?

Advancing age, particularly being 75 years or older, was independently associated with a significantly higher risk of elevated prothrombin-fragment 1+2 levels (OR 11.61) in cardiology outpatients.

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Key result

Advancing age, particularly being 75 years or older, was independently associated with a significantly higher risk of elevated prothrombin-fragment 1+2 levels (OR 11.61) in cardiology outpatients.

Population

773 cardiology outpatients. Key exclusions: presence of atrial fibrillation or deep venous thrombosis…

Design

Cross-sectional

Authors

AOAkinori OchiTsukuba Medical Center Hospital TATaro AdachiShowa University KIKoichiro InokuchiAichi Gakuin University

Discussion

Member takes

Implication

Age ≥75 associated with higher prothrombin-fragment 1+2 in outpatients; leaves open prospective validation before any risk-stratification role.

Study Design

Type

Cross-Sectional (n=773)

Multicenter

Structured PICO

Population

773 cardiology outpatients without atrial fibrillation or severe renal dysfunction, evaluated cross-sectionally for age-dependent changes in coagulation and fibrinolysis markers.

Outcome

Correlation between aging and blood markers of coagulation, fibrinolysis, and vascular endothelial function (D-dimer, F1+2, PIC, TM, TAT, tPAI-1, fibrinogen)surrogate

Main Result

Odds Ratio: 11.611 (95% CI 7.143–19.183)

p-value: p=<0.001

In real-world cardiology outpatients, hypercoagulable states and fibrinolytic activation develop with advancing age, particularly in those over 75 years, independent of other comorbidities.

Limitations

Single-center, cross-sectional study design with potential selection bias
Relatively small study population
Did not account for blood collection methods like needle gauge or seasonal variation
Did not exclude concomitant use of antiplatelet medication
Could not directly evaluate endothelial function
Single-center study
Sample size might not be large enough
Did not integrate gauge of needle or take seasonal variation into consideration
Could not directly evaluate endothelial function (e.g., flow-mediated dilation or ankle-brachial index)
Could not take into account activation of protein C

Cite This Study

Ochi et al. (2016) conducted a cross-sectional in Cardiology outpatients (n=773). Advancing age (≥75 years) vs. Age ≤64 years was evaluated on High prothrombin-fragment 1+2 (F1+2) level (≥230 pmol/L) (OR 11.611, 95% CI 7.143-19.183, p=<0.001). Advancing age, particularly being 75 years or older, was independently associated with a significantly higher risk of elevated prothrombin-fragment 1+2 levels (OR 11.61) in cardiology outpatients.

synapsesocial.com/papers/6a7d902787be3f923b5c97df https://doi.org/10.1253/circj.cj-16-0530

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January 1, 2016Circulation JournalOpen Access

Effects of Aging on the Coagulation Fibrinolytic System in Outpatients of the Cardiovascular Department

View Full Paper

Ask AI

Bookmark

Key result

Advancing age, particularly being 75 years or older, was independently associated with a significantly higher risk of elevated prothrombin-fragment 1+2 levels (OR 11.61) in cardiology outpatients.

Population

773 cardiology outpatients. Key exclusions: presence of atrial fibrillation or deep venous thrombosis…

Design

Cross-sectional

Authors

AOAkinori OchiTsukuba Medical Center Hospital TATaro AdachiShowa University KIKoichiro InokuchiAichi Gakuin University

Discussion

Member takes

Implication

Age ≥75 associated with higher prothrombin-fragment 1+2 in outpatients; leaves open prospective validation before any risk-stratification role.

Study Design

Type

Cross-Sectional (n=773)

Multicenter

Structured PICO

Population

773 cardiology outpatients without atrial fibrillation or severe renal dysfunction, evaluated cross-sectionally for age-dependent changes in coagulation and fibrinolysis markers.

Outcome

Correlation between aging and blood markers of coagulation, fibrinolysis, and vascular endothelial function (D-dimer, F1+2, PIC, TM, TAT, tPAI-1, fibrinogen)surrogate

Main Result

Odds Ratio: 11.611 (95% CI 7.143–19.183)

p-value: p=<0.001

In real-world cardiology outpatients, hypercoagulable states and fibrinolytic activation develop with advancing age, particularly in those over 75 years, independent of other comorbidities.

Limitations

Single-center, cross-sectional study design with potential selection bias
Relatively small study population
Did not account for blood collection methods like needle gauge or seasonal variation
Did not exclude concomitant use of antiplatelet medication
Could not directly evaluate endothelial function
Single-center study
Sample size might not be large enough
Did not integrate gauge of needle or take seasonal variation into consideration
Could not directly evaluate endothelial function (e.g., flow-mediated dilation or ankle-brachial index)
Could not take into account activation of protein C

Cite This Study

synapsesocial.com/papers/6a7d902787be3f923b5c97df https://doi.org/10.1253/circj.cj-16-0530

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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