Key result
Myocardial fibrosis is common in patients with congenital heart disease and is associated with arrhythmias, decreased functional status, and adverse ventricular mechanics.
Cardiac magnetic resonance imaging techniques like late gadolinium enhancement and extracellular volume mapping are emerging as key tools for detecting myocardial fibrosis and risk stratifying patients with congenital heart disease.
Supports fibrosis imaging for risk stratification in congenital heart disease; leaves open whether targeting it improves outcomes.
Myocardial fibrosis is common in patients with congenital heart disease (CHD) and has been associated with arrhythmias, decreased functional status, and adverse ventricular mechanics. There are multiple types of myocardial fibrosis that occur in response to different pathophysiologic stimuli. Recent advances in imaging technology have made detection and quantification of the types of myocardial fibrosis possible. In this review, we describe the pathophysiology of myocardial fibrosis, examine the imaging techniques used to evaluate fibrosis, and discuss the relationship between myocardial fibrosis and clinical outcomes in CHD. (Circ J 2016; 80: 1300-1307).
No takes yet. Share an insight, caveat, or question.
Rathod et al. (2016) conducted a review in Congenital Heart Disease. Myocardial fibrosis is common in patients with congenital heart disease and is associated with arrhythmias, decreased functional status, and adverse ventricular mechanics.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: