Key result
Absence of five major cardiovascular risk factors (hypertension, hyperlipidemia, abnormal weight, diabetes, and smoking) at midlife was associated with a substantial increase in longevity.
Why the study?
Does the absence of five major cardiovascular risk factors at midlife improve life expectancy in men and women?
Does the absence of five major cardiovascular risk factors at midlife improve life expectancy in men and women?
This letter highlights the omission of physical activity as a major risk factor in a large global analysis of cardiovascular risk factors and life expectancy.
To the Editor: In the study reported by Magnussen et al. on behalf of the Global Cardiovascular Risk Consortium (GCVRC) (July 10 issue), 1 the authors assessed the effect of five cardiovascular disease risk factors (hypertension, hyperlipidemia, underweight and overweight or obesity, diabetes, and smoking) at midlife on life expectancy in men and women from 133 international cohorts. 1 There was a substantial increase in longevity in the absence of these five risk factors in midlife. Although information on physical activity was available in many of the cohorts included in this analysis, the authors did not include it as a major risk . . .
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A 2025 study conducted a letter in Cardiovascular disease risk factors. Five cardiovascular disease risk factors (hypertension, hyperlipidemia, abnormal weight, diabetes, and smoking) vs. Absence of these risk factors was evaluated on Life expectancy. Absence of five major cardiovascular risk factors (hypertension, hyperlipidemia, abnormal weight, diabetes, and smoking) at midlife was associated with a substantial increase in longevity.
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