Key result
Short-term resistance training significantly improved blood lipid levels, regulated systolic blood pressure, and reduced inflammatory cytokine expression in diet-induced obese mice.
Why the study?
Regular exercise helps prevent and improve obesity, but the effects of short-term resistance training on weight loss, lipid profiles, blood pressure, atherogenic indices, and inflammation in middle-aged mice needed investigation.
Does short-term resistance training improve lipid metabolism and inflammation in diet-induced obese mice?
Does short-term resistance training improve lipid metabolism and inflammation in diet-induced obese mice?
Short-term resistance training improves blood lipids, inflammation profiles, regulates blood pressure, and improves atherosclerosis indices in diet-induced obese mice.
Answers are grounded in this paper and cite their sources.
Should not change clinical practice; leaves open translation of lipid, BP, and anti-inflammatory effects to humans.
Purpose: Obesity refers to a condition in which there is excessive fat in the body and is caused by an imbalanced diet and a decrease in physical activity.Accordingly, regular exercise is reported to help improve and prevent obesity.Therefore, this study investigated the effects of short-term resistance training (RT) on weight loss, lipid profiles, blood pressure, atherogenic indices, and inflammation in middle-aged mice.Methods: Adult mice (7.5-month-old) were randomly divided into three groups comprising 7 mice per group: a normal diet group (NDC); a high-fat diet group (HDC, 45% total calories as fat); and a high-fat diet plus resistance training group (HDRT).The mice in the resistance training group performed climbing exercises using a ladder for the experimental period of 5 days/week for 4 weeks.The indicated intensity load was adjusted by individual % of animal body weight.The load gradually increased every week, and a total of 4 repetitions/set and 3 sets/day with 1 minute of rest provided between sets were performed.After sacrifice, analysis of serum and mRNA expression in the tissues were performed. Results:The HDC group showed a significant increase in systolic blood pressure (SBP) compared to the NDC group, while the HDRT group had a lower SBP relative to the HDC group.RT significantly improved blood lipid levels (triglycerides [TG], low-density lipoprotein [LDL], non-high-density lipoprotein [nonHDL], and very-low-density lipoprotein cholesterol [VLDL-C]).Arteriosclerosis improved through resistance training as observed in the changes in the arteriosclerosis indices (atherogenic index of plasma [AIP], Castelli risk index [CRI]-I, CRI-II, and atherogenic coefficient [AC]).In addition, the HDRT group showed decreased mRNA expression levels of tumor necrosis factor-alpha (Tnfa), interleukin-1 beta (Il-1b), and Il-6 in muscle tissue when compared with the HDC. Conclusion:This study confirmed that RT improves blood lipids and inflammation profiles, regulates blood pressure, and improves atherosclerosis in obese mice.
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Cha et al. (2025) studied Diet-induced obesity (n=21). Short-term resistance training vs. High-fat diet without exercise was evaluated on Systolic blood pressure, blood lipid levels, and inflammatory markers (p=<0.05). Short-term resistance training significantly improved blood lipid levels, regulated systolic blood pressure, and reduced inflammatory cytokine expression in diet-induced obese mice.
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